HER2 Support Group Forums - View Single Post

Jean · 01-23-2008, 12:48 PM

Melissa,
Of course I don't mind your asking, that's why we are all here.
My tumor was graded 1 because it was well differentiated
but the character of the tumor was aggressive as my
KI-67 level was high. I am not certain that it is written in stone
that all Her2 + have to be grade 2 or 3. My Her2 +++ was
tested by both tests and twice by FISH and my FISH score was 15.

There is great reading on DCIS on our board - type in DCIS high recurrence in the search bar,
and also read the links posted by Lani. Good question on herceptin
when Her2 comes into the play. Just like early stagers at what point do you treat? Was a big question down in SA, the dr. are all divided.
Dr. Slamon believes all Her2 + should be treated with herceptin.
The standards are changing as we type. DCIS is not studied enough and there are studies currently going on but we do not have the data.

Yes, DCIS can come back and be invasive. There are different types of DCIS just like breast cancer. Most dr. treat it as a pre-cancer.
The links I mentioned will offer more detail.
Hope this helps.

As far as your friend, I will give you my case as a reference.
At first I was dx. with Stage 0 DCIS - my surgeon was still doing
a SNB..when he went in to do the lumpectomy the DCIS dx changed as the DCIS was
invasive..so now I was IDCIS...stage 1 - and note my tumor was very
tiny...3MM - There is so much debate over treatment. It becomes important for the patient to be hands on read the pathology report
and know what the margins were. Most often these days SNB is being done. Just curious of the size of her tumor, did she have radiation?

Kind Regards,
Jean

01-23-2008, 12:48 PM	#4
Jean Senior Member Join Date: Oct 2005 Location: New Jersey Posts: 3,154	Melissa, Of course I don't mind your asking, that's why we are all here. My tumor was graded 1 because it was well differentiated but the character of the tumor was aggressive as my KI-67 level was high. I am not certain that it is written in stone that all Her2 + have to be grade 2 or 3. My Her2 +++ was tested by both tests and twice by FISH and my FISH score was 15. There is great reading on DCIS on our board - type in DCIS high recurrence in the search bar, and also read the links posted by Lani. Good question on herceptin when Her2 comes into the play. Just like early stagers at what point do you treat? Was a big question down in SA, the dr. are all divided. Dr. Slamon believes all Her2 + should be treated with herceptin. The standards are changing as we type. DCIS is not studied enough and there are studies currently going on but we do not have the data. Yes, DCIS can come back and be invasive. There are different types of DCIS just like breast cancer. Most dr. treat it as a pre-cancer. The links I mentioned will offer more detail. Hope this helps. As far as your friend, I will give you my case as a reference. At first I was dx. with Stage 0 DCIS - my surgeon was still doing a SNB..when he went in to do the lumpectomy the DCIS dx changed as the DCIS was invasive..so now I was IDCIS...stage 1 - and note my tumor was very tiny...3MM - There is so much debate over treatment. It becomes important for the patient to be hands on read the pathology report and know what the margins were. Most often these days SNB is being done. Just curious of the size of her tumor, did she have radiation? Kind Regards, Jean __________________ Stage 1, Grade 1, 3/30/05 Lumpectomy 4/15/05 - 6MM IDC Node Neg. (Sentinel node) ER+ 90% / PR-, Her2+++ by FISH Ki-67 40% Arimidex 5/05 Radiation 32 trt, 5/30/05 Oncotype DX test 4/17/06, 31% high risk TOPO 11 neg. 4/06 Stopped Arimidex 5/06 TCH 5/06, 6 treatments Herceptin 5/06 - for 1 yr. 9/06 Completed chemo Started Femara Sept. 2006 Last edited by Jean; 01-23-2008 at 12:52 PM..