RE: Tamoxifen Resistance in Her2+, ER- & PR+
Katie,
We had some similar dicussions about Tamoxifen and HER2, I don't think the answer is clear:
http://her2support.org/vbulletin/showthread.php?t=30103
Since HER2+, ER- & PR+ is more rare, I couldn't find anything specific for you, but I have linked some articles of interest:
Tamoxifen for Patients With Estrogen Receptor–Negative Breast Cancer (2001)
http://jco.ascopubs.org/cgi/reprint/19/suppl_1/93s
What about Estrogen Receptor Negative Disease?
http://www.abreastinthewest.ca/news2.cfm?Num=61
Quantitative Measurement of Epidermal Growth Factor Receptor Is a Negative Predictive Factor for Tamoxifen Response in Hormone Receptor–Positive Premenopausal Breast Cancer
http://jco.ascopubs.org/cgi/content/abstract/25/21/3007
Compound Boosts Tamoxifen's Cancer-Fighting Power
http://www.medicineonline.com/news/1...ing-Power.html
Optimal Tumor Control in HER2-Positive Tumors Requires Complete Blockade
http://www.cancernetwork.com/tech-fo...leID=204805400
Early Results Suggest Small Benefit of Longer Tamoxifen Therapy
http://www.cancernetwork.com/tech-fo...leID=204805322
Tamoxifen does/doesn't work for HER2-positive?
http://www.breastcancer.org/news_res...uestion_17.jsp
Molecular Changes in Tamoxifen-Resistant Breast
Cancer: Relationship Between Estrogen Receptor, HER-2, and p38 Mitogen-Activated Protein Kinase
http://jco.ascopubs.org/cgi/reprint/23/11/2469
I hope that some of this information will help you to weigh the benefits and risks to help you find the best decision for you.
Best wellness wishes to you!
__________________
Aug06...Dx Age 50, IDC Left Breast, 6+/16 lymph nodes, Stg 3, ER+/PR+/HER2+
Sep06-Jan07...Mediport. Chemo: AC x 4, T x 4
Dec06-Nov07...Herceptin
Feb12,2007...Surg MRM Left & SM Right, reconstruct w/expanders
Mar07-Jun07...Saline Exp
Jun07...Start Tamoxifen
Jun07-Aug07...Rad x 25
Jun07-Oct07...Persistent fevers-unknown origin
Jun07-Nov07...PT for Severe PMPS & Capsular Contracture
Nov07...Surg Capsulectomy, Gel Implants, PMPS pain gone instantly.
Feb08...NED 1st CANCERVERSARY!!!!!
Feb08...2 months post surgery Caps Cont again :(
Mar08...Stop Tamoxifen. Start Arimidex.
Apr08...Sudden high fever, Hosp ICU 10 days, staph infect, emerg surg, implants removed. Outpt IVantibiotics Daily x 6 weeks
Feb11...NED 5th CANCERVERSARY!!!!!
Feb12...NED 6th CANCERVERSARY!!!!!
Aug12...Spotting. Surg=D&C
Sep12...STAGE IV = RARE BC METS TO UTERUS ILC ER+/PR+/HER2-Negative) (Different BC than originally diagnosed = IDC ER+/PR+/HER2+).
Sep12...Stop Arimidex. Start Afinitor & Aromasin.
Jan13...MRI = no progression no reduction
Apr13...Progression. Stop Afinitor & Aromasin.
Apr13...Start Chemo: Taxol & Carboplatin.
Nov13...Scans & Pelvic 95+% Reduction. Nueropathy>Stop chemo start Fareston.
Jan14...PET scan = no progression stable.
May14...Pelvic > Bleeding & cramps. TMs up.
May14...PET scan = uterine progression :(
May14...Stop Fareston. Start Chemo: Xeloda.
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