HER2 Support Group Forums - View Single Post - Tamoxifen Resistance in Her2+

wtfsanjo · 01-11-2008, 12:24 PM

So the CYP2DP test can tell us a lot about if tamoxifen would work for us were it not for the Her2+. The ostensible tamoxifen resistance in Her2+ still applies, even if the CYP2DP test indicates that we are good metabolizers of the drug. We can metabolize it well, but when it reaches the cancer cells, all the Her2 receptors block the tamoxifen from being able to impact the cell.

I wish none of this was even possibly true, because I really don't mind taking the tamoxifen - I feel like I could take it forever. But if i'm going to do hormone therapy, I want it to work, side effects or not.

ARGH! Cancer blows.

katie

01-11-2008, 12:24 PM	#17
wtfsanjo Member Join Date: Jan 2008 Posts: 10	So the CYP2DP test can tell us a lot about if tamoxifen would work for us were it not for the Her2+. The ostensible tamoxifen resistance in Her2+ still applies, even if the CYP2DP test indicates that we are good metabolizers of the drug. We can metabolize it well, but when it reaches the cancer cells, all the Her2 receptors block the tamoxifen from being able to impact the cell. I wish none of this was even possibly true, because I really don't mind taking the tamoxifen - I feel like I could take it forever. But if i'm going to do hormone therapy, I want it to work, side effects or not. ARGH! Cancer blows. katie __________________ Katie dx 11/15/06 @ 27 years old (now 29) 1.7cm IDC with extensive DCIS; no nodes ER-/PR+(10%)/Her2+++ grade 3 (9/9), Ki-67 85% DD AC/DD T, herceptin, tamoxifen bilateral mastectomy w/ saline impants