HER2 Support Group Forums - View Single Post - Celecoxib blocks morphine-induced tumor growth in mice

R.B. · 12-28-2007, 04:38 AM

The trial appeared to be concerned as to the impact of morphine in management of pain in cancer, and its effects.

This post begs questions as to the impacts of opiods in surgery in term of promoting growth.

Here is the link for what I guess is the trial referred to.

http://www.nature.com/bjc/journal/v9.../6604057a.html

"Morphine and its congener opioids are the main therapy for severe pain in cancer. However, chronic morphine treatment stimulates angiogenesis and tumour growth in mice."

"Two weeks of chronic morphine treatment at clinically relevant doses stimulates COX-2 and PGE2 (4.5-fold compared to vehicle alone) and angiogenesis in breast tumours in mice."

This is another trial that suggests morphine has a link to COX 2 products.

http://cat.inist.fr/?aModele=afficheN&cpsidt=17751681

RB

12-28-2007, 04:38 AM	#5
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	The trial appeared to be concerned as to the impact of morphine in management of pain in cancer, and its effects. This post begs questions as to the impacts of opiods in surgery in term of promoting growth. Here is the link for what I guess is the trial referred to. http://www.nature.com/bjc/journal/v9.../6604057a.html "Morphine and its congener opioids are the main therapy for severe pain in cancer. However, chronic morphine treatment stimulates angiogenesis and tumour growth in mice." "Two weeks of chronic morphine treatment at clinically relevant doses stimulates COX-2 and PGE2 (4.5-fold compared to vehicle alone) and angiogenesis in breast tumours in mice." This is another trial that suggests morphine has a link to COX 2 products. http://cat.inist.fr/?aModele=afficheN&cpsidt=17751681 RB