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Barbara2 · 12-22-2007, 01:43 PM

I'll post a question I asked of Dr. Pegram this past Spring:

Are the AI’s apt to stop working over time?

No, in fact right now they’re doing studies of 10 years vs. 5 years because in contrast to Tamoxifen which does apparently sort of “stop working” after 5 years, the AI’s may be a different story. They may continue to work. They work for at least 5 years and now there are big studies looking out to 10. There’s some theoretical rational why longer might actually be better with AIs. There may be a little hint of something that comes out from the longer term studies by next year.

12-22-2007, 01:43 PM	#7
Barbara2 Senior Member Join Date: Sep 2005 Location: South Dakota. Posts: 621	I'll post a question I asked of Dr. Pegram this past Spring: Are the AI’s apt to stop working over time? No, in fact right now they’re doing studies of 10 years vs. 5 years because in contrast to Tamoxifen which does apparently sort of “stop working” after 5 years, the AI’s may be a different story. They may continue to work. They work for at least 5 years and now there are big studies looking out to 10. There’s some theoretical rational why longer might actually be better with AIs. There may be a little hint of something that comes out from the longer term studies by next year. __________________ Blessings and Peace, Barbara DX Oct 02 @ age 52 Stage 2B Grade 3 Mastectomy "at least" 4.5 cm IDC 1+node ER+61% /PR- Assiciated Intraductual component with Comedo Necrosis Her2+ FISH8.6 IHC 2+ 5 1/2 CEF Arimidex Celebrex 400mg daily for 13 months Prophylactic mastectomy Estradiol #: 13 PTEN positive, "late" Herceptin (26 months after chemo) Oct 05: Actonel for osteopenia from Arimidex. May 08: Replaced Actonel with Zometa . Taking every 6 months. Accepting the gift of life, I give thanks for it and live it in fullness.