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Sheila - I am betting that she did stop by our booth - but we didn't know it. I believe she is hoping to retain her "incognito" status.
Flori and all - I think I tuned in to much of the info that Lani is talking about at SABCS, and I too wait with baited breath for her distillation of the very powerful developments and research regarding HER2. There are some very elegant researchers working on breaking the code of our particular subset of the disease. There was so much that I found to be over the moon optimistic about, but I have no idea how to translate it accurately. All I know is that I heard two researchers use the phrase "on path to potential cure" and I know that they didn't say it lightly. Those are strong words to use in such a setting. But they are breaking the complex code and network of HER1, 2, 3, 4 and the synergy and escape hatches that those genes/proteins have heretofore used to proliferate. There are some very smart theories out there and we as patients in the immediate might be able to offer something that can contribute greatly to advancing those theories. It would be generous of us to give Lani a moment to catch her breath to congeal the info she acquired, so that she can present it to us in an understandable way. For her to be there acting on our behalf so directly with the researchers is a generousity that I can hardly wrap my mind around... All I can think to say is, THANK YOU Lani. (I actually smiled at her attempt at ironic humor due to her exhaustion. I knew exactly what she meant... that she knew it might be a little cruel to have only the energy to post a small taster of the info she acquired, for those of us waiting with baited breath - but she was excited and wanted everyone to know that there is much to be excited about and that she has every intention to post the nitty gritty details at her very earliest opportunity. It was not malicious, just a stab at gently irony.)
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Brenda
NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)
Nov'03~ dX stage 2B
Dec'03~ Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~ Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~ micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~ micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg
Apr'07~ MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~ Started Tykerb/Xeloda, no WBR for now
June'07~ MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~ MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~ PET/CT & MRI show NED
Apr'08~ scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~ MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~ dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~ Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~ new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~ new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~ 25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.
"I would rather be anecdotally alive than statistically dead."
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