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Lani · 12-17-2007, 09:16 AM

there are trials begnning with tykerb and herceptin. and the safety phase so far has shown no additional toxicity, but the trials are still new and not all side effects show themselves right away.

There is also the new chemofused to herceptin being developed by GENENTECH, Pertuzumab plus herceptin already some interim reports in metastatic her2+ bc were reported at ASCO --and the safety phase so far has shown no additional toxicity, but the trials are still new and not all side effects show themselves right away. in addition there were initial reports on herceptin plus an mTor inhibitor, an Hsp90 inhibitor and others. Lots of those posters were up on Sunday morning or Saturday afternoon poster sessions as I recall.

I would think by donating portions of their biopsy specimens patients could contribute to speeding up this process, as it is essential to see which pathways contribute in each patient to the aggressiveness of their tumor to find biomarkers to determine in which patients to test each of these combinations. If they would not have found FISH by her2 as a marker for herceptin, herceptin trials would have failed to show efficacy and the drug would not have been developed!!!

Sorry to sound like a bully on the pulpit, a nagging mother/spouse/mother-in law, but how many would like to step up to the plate or are you one would would rather wait around for something to be found, developed, tested, approved (which could be ten to twenty years)?

12-17-2007, 09:16 AM	#10
Lani Senior Member Join Date: Mar 2006 Posts: 4,780	John 21 there are trials begnning with tykerb and herceptin. and the safety phase so far has shown no additional toxicity, but the trials are still new and not all side effects show themselves right away. There is also the new chemofused to herceptin being developed by GENENTECH, Pertuzumab plus herceptin already some interim reports in metastatic her2+ bc were reported at ASCO --and the safety phase so far has shown no additional toxicity, but the trials are still new and not all side effects show themselves right away. in addition there were initial reports on herceptin plus an mTor inhibitor, an Hsp90 inhibitor and others. Lots of those posters were up on Sunday morning or Saturday afternoon poster sessions as I recall. I would think by donating portions of their biopsy specimens patients could contribute to speeding up this process, as it is essential to see which pathways contribute in each patient to the aggressiveness of their tumor to find biomarkers to determine in which patients to test each of these combinations. If they would not have found FISH by her2 as a marker for herceptin, herceptin trials would have failed to show efficacy and the drug would not have been developed!!! Sorry to sound like a bully on the pulpit, a nagging mother/spouse/mother-in law, but how many would like to step up to the plate or are you one would would rather wait around for something to be found, developed, tested, approved (which could be ten to twenty years)?