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My nails have always been thin and break easily, and Herceptin didn't change them for better or worse, BUT after being on Taxotere/Xeloda/Herceptin this fall my fingernails and toenails are discolored, lifting away from the nail beds, I've lost one toenail and fingernail and expect several more will eventually give up the ghost. I think it was the combo of Taxotere/Xeloda, as I had Taxol by itself years ago with no nail issues, and was recently on Xeloda/Herceptin for over a year with no problem.
Yes, small price to pay, but even so a bit depressing as you don't realize how handy your nails are for picking up small things and getting a grip on lids, etc.
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Sept.'99 - Dx.Stage IIIB, IDC ER/PR-, HER2+++ by IHC, confirmed '04 by FISH. Left MRM, AC x's 4, Taxol x's 4, 33 Rads, finishing Tx May 2000. Jan.'01 - local/regional recurrence, Stage IV. Herceptin/Navelbine weekly till NED August 2001, then maintenance Herceptin. Right Mast. April 2002. Local/Regional recurrence April '04, Herceptin plus/minus chemo until May '07. Gemzar added from Feb.'07-April '07; Tykerb/Abraxane until August '07, back on Herceptin plus Taxotere and Xeloda Sept. '07. Stopped T/X Nov. '07, stopped Herceptin Dec. '07, started Avastin/Taxol/Carboplatin Dec. '07. Progression in chest skin, stopped TAC March '03, started radiation.
Herceptin has served as the "Backbone" of my treatment strategy for over 6 years, giving me great quality of life. In 2005, I was privileged to participate in the University of Washington/Seattle HER2 Vaccine Trial.
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