HER2 Support Group Forums - View Single Post - bones of breast cancer patients aged prematurely by treatment

Christine MH-UK · 11-26-2007, 12:46 PM

I found this on Medline:</PRE>
1: Oncol Nurs Forum. 2007 May;34(3):627-33.Exercise effects on bone mineral density in women with breast cancer receivingadjuvant chemotherapy.Schwartz AL, Winters-Stone K, Gallucci B.The Scottsdale Healthcare Cancer Research Endowed Chair, Arizona StateUniversity, Phoenix, AZ, USA. annaschwartz@peoplepc.comPURPOSE/OBJECTIVES: To test the effects of aerobic and resistance exercise onchanges in bone mineral density (BMD) in women newly diagnosed with stage I-IIIbreast cancer receiving chemotherapy. DESIGN: Randomized clinical trial. SETTING:Two National Cancer Institute-designated cancer centers in metropolitan areas.SAMPLE: 66 women with stage I-III breast cancer beginning adjuvant chemotherapy. METHODS: Participants were randomized to aerobic or resistance exercise and usualcare. At the beginning of chemotherapy and at six months, patients completedexercise testing and BMD assessment of the lumbar spine by dual energy x-rayabsorptionetry. MAIN RESEARCH VARIABLES: BMD, aerobic capacity, and musclestrength. FINDINGS: The average decline in BMD was -6.23% for usual care, -4.92% for resistance exercise, and -0.76% for aerobic exercise. Aerobic exercisepreserved BMD significantly better compared to usual care. Premenopausal womendemonstrated significantly greater declines in BMD than postmenopausal women.Aerobic capacity increased by almost 25% for women in the aerobic exercise group and 4% for resistance exercise. Participants in the usual care group showed a 10%decline in aerobic capacity. CONCLUSIONS: The data suggest that weight-bearingaerobic exercise attenuates declines in BMD and that aerobic and resistanceexercise improve aerobic capacity and muscle strength at a time when womengenerally show marked declines in functional ability. IMPLICATIONS FOR NURSING:Exercise may prevent or at least minimize bone loss observed during chemotherapy and may prevent or delay the long-term effects of osteoporosis.Publication Types: Comparative Study Randomized Controlled TrialPMID: 17573321 [PubMed - indexed for MEDLINE]</PRE>

11-26-2007, 12:46 PM	#4
Christine MH-UK Senior Member Join Date: Sep 2005 Posts: 414	Some recent research suggests benefit of exercise I found this on Medline:</PRE> 1: Oncol Nurs Forum. 2007 May;34(3):627-33.Exercise effects on bone mineral density in women with breast cancer receivingadjuvant chemotherapy.Schwartz AL, Winters-Stone K, Gallucci B.The Scottsdale Healthcare Cancer Research Endowed Chair, Arizona StateUniversity, Phoenix, AZ, USA. annaschwartz@peoplepc.comPURPOSE/OBJECTIVES: To test the effects of aerobic and resistance exercise onchanges in bone mineral density (BMD) in women newly diagnosed with stage I-IIIbreast cancer receiving chemotherapy. DESIGN: Randomized clinical trial. SETTING:Two National Cancer Institute-designated cancer centers in metropolitan areas.SAMPLE: 66 women with stage I-III breast cancer beginning adjuvant chemotherapy. METHODS: Participants were randomized to aerobic or resistance exercise and usualcare. At the beginning of chemotherapy and at six months, patients completedexercise testing and BMD assessment of the lumbar spine by dual energy x-rayabsorptionetry. MAIN RESEARCH VARIABLES: BMD, aerobic capacity, and musclestrength. FINDINGS: The average decline in BMD was -6.23% for usual care, -4.92% for resistance exercise, and -0.76% for aerobic exercise. Aerobic exercisepreserved BMD significantly better compared to usual care. Premenopausal womendemonstrated significantly greater declines in BMD than postmenopausal women.Aerobic capacity increased by almost 25% for women in the aerobic exercise group and 4% for resistance exercise. Participants in the usual care group showed a 10%decline in aerobic capacity. CONCLUSIONS: The data suggest that weight-bearingaerobic exercise attenuates declines in BMD and that aerobic and resistanceexercise improve aerobic capacity and muscle strength at a time when womengenerally show marked declines in functional ability. IMPLICATIONS FOR NURSING:Exercise may prevent or at least minimize bone loss observed during chemotherapy and may prevent or delay the long-term effects of osteoporosis.Publication Types: Comparative Study Randomized Controlled TrialPMID: 17573321 [PubMed - indexed for MEDLINE]</PRE>