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StephN · 11-20-2007, 08:02 PM

Tanespimycin (was known as KOS-953) is taken with Herceptin. One drawback is that you can't have had a regimen that included Herceptin. This drug is used for multiple myloma and other conditions, and may be avail off label.

Tanespimycin is an Hsp90 inhibitor that has demonstrated the potential to disrupt the activity of multiple oncogenes and cell signaling pathways implicated in tumor growth, including HER2, a key pathway in breast cancer.

I am posting this as it seems to have gone under the radar of the clinical trial sleuths we have here.

Definition from the National Cancer Institute:
tanespimycin
A benzoquinone antineoplastic antibiotic derived from the antineoplastic antibiotic geldanamycin. Tanespimycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be overexpressed by tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

Kosan's Hsp90 Inhibitor, Tanespimycin, Shows Promising Antitumor Activity In Phase 2 Trial Of Patients With HER2-Positive Metastatic Breast Cancer

Link to the info from San Antonio last year - I am sure there will be an update this year:

http://www.medicalnewstoday.com/articles/59083.php

I have a friend here who is on this trial - she was number 7 enrolled. She says there are now some 40 women enrolled and the trial has more sites. She has tumors in unusual places (on aorta for one) and during her neoadjuvent treatment her primary tumor grew from 1.5 to 8 cm and metastesized. Her disease is VERY agressive and hard to halt. In a little over a year her tumors have shrunk and nothing new. She keeps her hair and can still work.

Just wanted to mention this as some here are seeking new treatment for advancing disease and here is something with a new twist, working against the heat shock protein as well as HER2 pathways.

11-20-2007, 08:02 PM	#1
StephN Senior Member Join Date: Nov 2004 Location: Misty woods of WA State Posts: 4,128	HER2 bc mets? New drug show MUCH promise Tanespimycin (was known as KOS-953) is taken with Herceptin. One drawback is that you can't have had a regimen that included Herceptin. This drug is used for multiple myloma and other conditions, and may be avail off label. Tanespimycin is an Hsp90 inhibitor that has demonstrated the potential to disrupt the activity of multiple oncogenes and cell signaling pathways implicated in tumor growth, including HER2, a key pathway in breast cancer. I am posting this as it seems to have gone under the radar of the clinical trial sleuths we have here. Definition from the National Cancer Institute: tanespimycin A benzoquinone antineoplastic antibiotic derived from the antineoplastic antibiotic geldanamycin. Tanespimycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be overexpressed by tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) Kosan's Hsp90 Inhibitor, Tanespimycin, Shows Promising Antitumor Activity In Phase 2 Trial Of Patients With HER2-Positive Metastatic Breast Cancer Link to the info from San Antonio last year - I am sure there will be an update this year: http://www.medicalnewstoday.com/articles/59083.php I have a friend here who is on this trial - she was number 7 enrolled. She says there are now some 40 women enrolled and the trial has more sites. She has tumors in unusual places (on aorta for one) and during her neoadjuvent treatment her primary tumor grew from 1.5 to 8 cm and metastesized. Her disease is VERY agressive and hard to halt. In a little over a year her tumors have shrunk and nothing new. She keeps her hair and can still work. Just wanted to mention this as some here are seeking new treatment for advancing disease and here is something with a new twist, working against the heat shock protein as well as HER2 pathways. __________________ "When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau Live in the moment. MY STORY SO FAR ~~~~ Found suspicious lump 9/2000 Lumpectomy, then node dissection and port placement Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR - Adriamycin 12 weekly, taxotere 4 rounds 36 rads - very little burning 3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED! 2003 & 2004 no active disease - 3 weekly Herceptin + Zometa Jan 2005 two mets to brain - Gamma Knife on Jan 18 All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying Continue as NED while on Herceptin & quarterly Zometa Fall-2006 - off Zometa - watching one small brain spot (scar?) 2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava 2008 - Brain and body still NED! Port removed and scans in Dec. Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011 STILL NED everywhere in Feb 2014 - on wing & prayer 7/14 - Started twice yearly Zometa for my bones Jan. 2015 checkup still shows NED 2015 Neuropathy in feet - otherwise all OK - still NED. Same news for 2016 and all of 2017. Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.