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John,
I'm so very glad to see (however late I might be) that you've had these great replies. And, glad that you went directly to the PM to reach me...
Other than what I've said already, the fact that your wife has two lesions that appear to be bleeding really worries me as to what will be recommended...
A combination of surgical and focalized radiation may be an option, if the problematic lesions are accessible. I've not had nor seen any one else with this particular problem before.
As you may have gleaned, WBR does not have that great of a 'duratation' if indeed successful in the first place. That was one (two) of my reasons for rejecting it, no matter what scare was put to me.
I went in with as much knowledge as I could, listened carefully, stated my wishes, then said: "I'd rather wait and see" for the WBR. I did have a hard time getting what I wanted and was not treated well because of it...
I much preferred the CyberKnife over the other focalized, simply because it saved me from that damned screwed on headframe. Three times of that was way enough. Once I could have lived with!
As for chemos, as I told you, my success with Xeloda/Temodar has been very good. And the Xeloda might address your wife's remaining breast tumor, too. Who knows in advance? No one.
I believe after a time her heart should recover and the Tykerb could be looked at then.
we're all pulling for you,
patty
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