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jml · 10-15-2007, 06:13 AM

"...general anaesthesia causes angiogenesis, then wouldn't the control arm be the same procedure not done under general anaesthesia?"

It's my understanding that the other group in the study underwent some type of Nerve Block to isolate & locally anesthetize the surgical area during their surgeries.

The study discussing the correlation between General Anesthesia & BC met activity suggests that it is some component in the drug combination used to anesthetize that may encourage angiogenesis.

We already know what the body must do in order to heal - from surgery or any other trauma or injury - increased Her2 production & all other growth factors & angiogenic activity.
But, how can we avoid or minimize these effects, specifically relative to "dormant" micromets, if surgery can't be avoided?
That is the real question.

We also already understand how significant ANTI-angiogenics, like Avastin & Thalidomide, are in cancer treatment.
This study reveals new information about a potentially PRO-angiogenic drug combo in General Anesthesia.

I'll search for more info on the study, maybe even find an abstract on the ASA website - or here's the web address if anyone else is so inclined:
http://www2.asahq.org/web/index.asp.

ps-general anesthesia is rarely used in a diagnostic colonoscopy.

10-15-2007, 06:13 AM	#10
jml Senior Member Join Date: Dec 2006 Posts: 415	General Anesthesia & angiogenesis vs. Nerve block "...general anaesthesia causes angiogenesis, then wouldn't the control arm be the same procedure not done under general anaesthesia?" It's my understanding that the other group in the study underwent some type of Nerve Block to isolate & locally anesthetize the surgical area during their surgeries. The study discussing the correlation between General Anesthesia & BC met activity suggests that it is some component in the drug combination used to anesthetize that may encourage angiogenesis. We already know what the body must do in order to heal - from surgery or any other trauma or injury - increased Her2 production & all other growth factors & angiogenic activity. But, how can we avoid or minimize these effects, specifically relative to "dormant" micromets, if surgery can't be avoided? That is the real question. We also already understand how significant ANTI-angiogenics, like Avastin & Thalidomide, are in cancer treatment. This study reveals new information about a potentially *PRO-angiogenic* drug combo in General Anesthesia. I'll search for more info on the study, maybe even find an abstract on the ASA website - or here's the web address if anyone else is so inclined: http://www2.asahq.org/web/index.asp. ps-general anesthesia is rarely used in a diagnostic colonoscopy.