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Lani · 10-14-2007, 02:01 PM

general anaesthesia causes angiogenesis, then wouldn't the control arm be the same procedure not done under general anaesthesia?

We know surgery produces angiogenic responses (if it did not, surgeries and injuries and inflammatory conditions would never heal). It is theorized that the bigger the surgery the greater the angiogenic response, although I don't know that this has been proven, hence the trend to needle biopsies and the trend away from mastectomies.

I guess the question is how much more angiogenic response is there if you add general anaesthesia to the trauma of surgery...and then there is the fact that the angiogenic response differs according to the phase of the menstrual cycle the surgery is performed in and certainly other variables as well.

Let's hope they can sort this out well enough to give informed recommendations.

10-14-2007, 02:01 PM	#6
Lani Senior Member Join Date: Mar 2006 Posts: 4,783	Becky I have not had time to read the article but if it claims general anaesthesia causes angiogenesis, then wouldn't the control arm be the same procedure not done under general anaesthesia? We know surgery produces angiogenic responses (if it did not, surgeries and injuries and inflammatory conditions would never heal). It is theorized that the bigger the surgery the greater the angiogenic response, although I don't know that this has been proven, hence the trend to needle biopsies and the trend away from mastectomies. I guess the question is how much more angiogenic response is there if you add general anaesthesia to the trauma of surgery...and then there is the fact that the angiogenic response differs according to the phase of the menstrual cycle the surgery is performed in and certainly other variables as well. Let's hope they can sort this out well enough to give informed recommendations.