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Hi Leslie, I'm a Leslie ie too. I have been on tamoxifen for 31/2 years, I have tolerated it very well.I take it at night and have never had any nausea. I have had hot flashes but they are getting better,I was on paxil and read that tamoxifen was not as effective I think that this was true for me because my estrogen # was over 200 and after stopping the paxil it dropped to 28 and I have not had a period since Feb 07 so I think that I would rather deal with hot flashes.goodluck leslie
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