HER2 Support Group Forums - View Single Post - Alcohol increases breast cancer risk by 10% and 40%

R.B. · 10-13-2007, 04:04 AM

And in the lab alcohol pushes up aromatase expression.

RB

http://www.ncbi.nlm.nih.gov/sites/en...RVAbstractPlus

Ethanol stimulates proliferation, ERalpha and aromatase expression in MCF-7 human breast cancer cells.
Etique N, Chardard D, Chesnel A, Merlin JL, Flament S, Grillier-Vuissoz I.

ABSTRACT

"At the same stage, RT-PCR studies demonstrate a 2.4-fold increase in aromatase mRNA level which is confirmed at the protein level by western blots performed after immuno-precipitation of the enzyme. Taken together, these results are in agreement with the involvement of ER signalling in ethanol-induced stimulation of breast cancer cell proliferation and could help to understand why alcohol consumption is associated with breast cancer risk."

10-13-2007, 04:04 AM	#10
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	And in the lab alcohol pushes up aromatase expression. RB http://www.ncbi.nlm.nih.gov/sites/en...RVAbstractPlus Ethanol stimulates proliferation, ERalpha and aromatase expression in MCF-7 human breast cancer cells. Etique N, Chardard D, Chesnel A, Merlin JL, Flament S, Grillier-Vuissoz I. ABSTRACT "At the same stage, RT-PCR studies demonstrate a 2.4-fold increase in aromatase mRNA level which is confirmed at the protein level by western blots performed after immuno-precipitation of the enzyme. Taken together, these results are in agreement with the involvement of ER signalling in ethanol-induced stimulation of breast cancer cell proliferation and could help to understand why alcohol consumption is associated with breast cancer risk."