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Mary Anne
As I understand it, the DM1 drug is even larger than herceptin because it is a herceptin antibody linked to a chemotherapy drug. It is not a pro-drug as I understand it (one in which the two parts of the combination are separated before the drug works, for example by processing in the liver)
So if you are looking for a "smaller herceptin" perhaps that is what you or someone else called a receptor tyrosine kinase inhibitor (like Tykerb) or an interfering RNA (none have yet been developed into drugs and unfortunately it looks like a while before they do) or perhaps something else altogether. Please let me know when you find the link you are referring to--maybe it is something I have missed altogether(very possible despite the volume of my reading)
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