HER2 Support Group Forums - View Single Post

Joanne S · 09-13-2007, 07:20 PM

You cannot inherit HER2. It is not Hereditary:
I agree the information I posted from herceptin.com site is simplified. And it's straight forward.

Lani,

Honestly, I am pretty ignorant to your two posts.---they are really over my head.

I don't see anywhere (or maybe just don't understand) where either post implies that Her2+ is hereditary.

My simplified drift on your posts
-HER2 is more apt to show up in first degree family members (than in sporadic cases) in familial cases that have specific features (poorly differentiated tumors, large tumors, more lymph involve....lots of other clinicobiologic features....)
-FOXP3 is an X-linked breast cancer suppressor gene and an important regulator of the HER-2/ErbB2 oncogene? All I get out of this is that FOXP3 has an impact on HER2 amplification. This entire post is over my head.
-"IF TRUE, YOU MAY BE ABLE TO TEST YOUR DAUGHTERS and
if true, they may be able to prevent supression of the suppressor." Your comment totally confused me????

I appreciate your input. I mean no disrespect to you nor am I challenging you. Just seeking clarification. I tend to stick with the more easy to understand simplied facts regarding what's currently available and going on now (less about trials and studies). I'm pretty simple minded.

Sincerely.

09-13-2007, 07:20 PM	#5
Joanne S Senior Member Join Date: Aug 2007 Location: Detroit Metropolitan Area, Michigan Posts: 592	You cannot inherit HER2. It is not Hereditary: I agree the information I posted from herceptin.com site is simplified. And it's straight forward. Lani, Honestly, I am pretty ignorant to your two posts.---they are really over my head. I don't see anywhere (or maybe just don't understand) where either post implies that Her2+ is hereditary. My simplified drift on your posts -HER2 is more apt to show up in first degree family members (than in sporadic cases) in familial cases that have specific features (poorly differentiated tumors, large tumors, more lymph involve....lots of other clinicobiologic features....) -FOXP3 is an X-linked breast cancer suppressor gene and an important regulator of the HER-2/ErbB2 oncogene? All I get out of this is that FOXP3 has an impact on HER2 amplification. This entire post is over my head. -"IF TRUE, YOU MAY BE ABLE TO TEST YOUR DAUGHTERS and if true, they may be able to prevent supression of the suppressor." Your comment totally confused me???? I appreciate your input. I mean no disrespect to you nor am I challenging you. Just seeking clarification. I tend to stick with the more easy to understand simplied facts regarding what's currently available and going on now (less about trials and studies). I'm pretty simple minded. Sincerely. __________________ Aug06...Dx Age 50, IDC Left Breast, 6+/16 lymph nodes, Stg 3, ER+/PR+/HER2+ Sep06-Jan07...Mediport. Chemo: AC x 4, T x 4 Dec06-Nov07...Herceptin Feb12,2007...Surg MRM Left & SM Right, reconstruct w/expanders Mar07-Jun07...Saline Exp Jun07...Start Tamoxifen Jun07-Aug07...Rad x 25 Jun07-Oct07...Persistent fevers-unknown origin Jun07-Nov07...PT for Severe PMPS & Capsular Contracture Nov07...Surg Capsulectomy, Gel Implants, PMPS pain gone instantly. Feb08...NED 1st CANCERVERSARY!!!!! Feb08...2 months post surgery Caps Cont again :( Mar08...Stop Tamoxifen. Start Arimidex. Apr08...Sudden high fever, Hosp ICU 10 days, staph infect, emerg surg, implants removed. Outpt IVantibiotics Daily x 6 weeks Feb11...NED 5th CANCERVERSARY!!!!! Feb12...NED 6th CANCERVERSARY!!!!! Aug12...Spotting. Surg=D&C Sep12...STAGE IV = RARE BC METS TO UTERUS ILC ER+/PR+/HER2-Negative) (Different BC than originally diagnosed = IDC ER+/PR+/HER2+). Sep12...Stop Arimidex. Start Afinitor & Aromasin. Jan13...MRI = no progression no reduction Apr13...Progression. Stop Afinitor & Aromasin. Apr13...Start Chemo: Taxol & Carboplatin. Nov13...Scans & Pelvic 95+% Reduction. Nueropathy>Stop chemo start Fareston. Jan14...PET scan = no progression stable. May14...Pelvic > Bleeding & cramps. TMs up. May14...PET scan = uterine progression :( May14...Stop Fareston. Start Chemo: Xeloda.