[PinkGirl]

I am also very interested in knowing the physiological cause of the joint pain while on Arimidex. Because my memory has also gone down the drain, I am not sure how long I have been on it, but it is probably around one year. I think of it as "arthritic-like" pain, but maybe the lack of estrogen and calcium, and the bone loss means it is arthritic pain.

I also feel much older than my years and my joints don't want to move after I have been sitting down or lying down for awhile. But once I manage to get up and walk for a few minutes, I am fine. If I have a busy day, the next day I will be exhausted. I have started taking Glucosamine for the joint pain but haven't been on it long enough to judge if it is working. Like you Debbie, I have bazaar hot flashes. I also get the "pins and needles" thing. Sometimes my hot flashes are like mini panic attacks.

Today I purchased a bike (outdoor) and I am going to start riding it around the block. I also bought a helmet!!!

I have never heard or read of an explanation of why we get joint pain from this drug.

Good luck to everyone with this.