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Old 08-12-2007, 10:53 AM   #1
AlaskaAngel
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Join Date: Sep 2005
Location: Alaska
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Question Antiestrogen conclusion (SERMs and AIs)

How many with bc are aware of this scientific conclusion:

"According to Lombardi medical oncologist Minetta Liu, MD, it is expected that all hormone receptor positive metastatic breast cancers will eventually develop resistance to endocrine therapies."

and

"Anti-hormonal therapies are some of the most effective treatments for breast cancer because estrogen, a natural female sex hormone, can drive the growth of the tumor. Tamoxifen and other anti-hormonal therapies cut off the tumor’s access to estrogen, causing the tumor to stabilize and sometimes even shrink. However according to Clarke, many cancers become insensitive to these treatments over time – more than half of all recurring breast cancers lose sensitivity – because they have found a way to keep growing in the absence of estrogen."<O</O

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