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Old 08-09-2007, 12:29 AM   #17
danceswithrain
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Join Date: Jun 2007
Location: Alaska/arizona
Posts: 26
me again hope today is better for you. here is some info on dose reduction re: TCH if you have severe neuopathy.I've included the link if you want to read the whole article but you might want to bring this info to your Dr. to see if a dose reduction is possible.

http://www.ncbi.nlm.nih.gov/sites/en...=pubmed_docsum

Dosage Adjustments During Treatment
Breast Cancer
Patients who are dosed initially at 100 mg/m<SUP>2</SUP> and who experience either febrile neutropenia, neutrophils < 500 cells/mm<SUP>3</SUP> for more than 1 week, or severe or cumulative cutaneous reactions during TAXOTERE therapy should have the dosage adjusted from 100 mg/m<SUP>2</SUP> to 75 mg/m<SUP>2</SUP>. If the patient continues to experience these reactions, the dosage should either be decreased from 75 mg/m<SUP>2</SUP> to 55 mg/m<SUP>2</SUP> or the treatment should be discontinued. Conversely, patients who are dosed initially at 60 mg/m<SUP>2</SUP> and who do not experience febrile neutropenia, neutrophils <500 cells/mm<SUP>3</SUP> for more than 1 week, severe or cumulative cutaneous reactions, or severe peripheral neuropathy during TAXOTERE therapymay tolerate higher doses. Patients who develop ≥ grade 3 peripheral neuropathy should have TAXOTERE treatment discontinued entirely.

Hugs!!!
Vicki
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Vicki
dia 4/07 stage 3 grade2
4.3cm w/enlarge lymph nodes;
er/pr-,HER2+++;Ki67 55%
TCH X3 every 3wks till 8/7/07,
Herceptin till 4/4/08
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