HER2 Support Group Forums - View Single Post - total regression of orthotopic (implanted) tumors with RNAi to uPARR, MMP9

R.B. · 07-31-2007, 02:27 PM

http://www.ncc.go.jp/en/nccri/annrep....Chemothe.html

On my web wanders again!

This is for a different cancer and this is all there is - thought provoking none the less.

RB

Abstact

Inhibitory Effects of Oleic and Docosa-hexaenoic Acids on Lung Metastatic Colony Formation and Matrix Metalloproteinase (MMP) Activity

Oleic acid (OA) and docosahexaenoic acid (DHA) were found to significantly inhibit lung metastasis in a colon carcinoma-26 tumor cell metastasis assay system, the fatty acids being well absorbed into tumor tissues. Arachidonic acid and linoleic acid contents were markedly decreased by treatment with DHA. Gelatinolytic activity of the 57-kD (MMP-2) and 92-kD (MMP-9) isoforms of type-IV collagenase showed a clear reduction with OA and DHA, respectively. These results suggest that the effects of OA and DHA on metastasis might be due to inhibition of type-IV collagenase activity.(52-54)

07-31-2007, 02:27 PM	#2
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	DHA and oleic acid inhibit MMP 9? http://www.ncc.go.jp/en/nccri/annrep....Chemothe.html On my web wanders again! This is for a different cancer and this is all there is - thought provoking none the less. RB Abstact Inhibitory Effects of Oleic and Docosa-hexaenoic Acids on Lung Metastatic Colony Formation and Matrix Metalloproteinase (MMP) Activity Oleic acid (OA) and docosahexaenoic acid (DHA) were found to significantly inhibit lung metastasis in a colon carcinoma-26 tumor cell metastasis assay system, the fatty acids being well absorbed into tumor tissues. Arachidonic acid and linoleic acid contents were markedly decreased by treatment with DHA. Gelatinolytic activity of the 57-kD (MMP-2) and 92-kD (MMP-9) isoforms of type-IV collagenase showed a clear reduction with OA and DHA, respectively. These results suggest that the effects of OA and DHA on metastasis might be due to inhibition of type-IV collagenase activity.(52-54)