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Lani · 07-20-2007, 11:41 AM

that different amounts of the same compound cause differing (even opposite effects) It may be that some feedback mechanism only comes into place when a threshold has been exceeded and that feedback mechanism changes which pathway is dominant.l

Thinks of a line at the airport with a person feeding people into different lines. Once the lines get too long, people may be ciphoned off to automated machines, other checkin desks, or told to go with another airline.

The body has to prioritize and have ways for different amounts of substances to be processed as well.

The reason the estradiol had no effect initially is that faslodex had caused the ERs to degrade and there was no receptor to work on. But Estrogen also has effects on the membrane and cytoplasm besides effects on the nucleus (and probably lots of other effects even less well described or not yet discovered!)

The important point was that a certain concentration (and we do not yet know what that is in humans) soy isoflavones could decrease/possibly negate the effects of Faslodex, so caution might be prudent until this is better understood

Hope this helps!

07-20-2007, 11:41 AM	#6
Lani Senior Member Join Date: Mar 2006 Posts: 4,783	Hopeful--this is a widespread phenomenon in physiology/pharmacology that different amounts of the same compound cause differing (even opposite effects) It may be that some feedback mechanism only comes into place when a threshold has been exceeded and that feedback mechanism changes which pathway is dominant.l Thinks of a line at the airport with a person feeding people into different lines. Once the lines get too long, people may be ciphoned off to automated machines, other checkin desks, or told to go with another airline. The body has to prioritize and have ways for different amounts of substances to be processed as well. The reason the estradiol had no effect initially is that faslodex had caused the ERs to degrade and there was no receptor to work on. But Estrogen also has effects on the membrane and cytoplasm besides effects on the nucleus (and probably lots of other effects even less well described or not yet discovered!) The important point was that a certain concentration (and we do not yet know what that is in humans) soy isoflavones could decrease/possibly negate the effects of Faslodex, so caution might be prudent until this is better understood Hope this helps!