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Terri
I believe that while on Herceptin, tamoxifen is fine but it is not fine if it is used as a single treatment (blocking just the estrogen receptor but leaving the Her2 receptor open and exposed).
After Herceptin is concluded, Faslodex or an AI should be used as Tamoxifen resistance (really doesn't mean that it doesn't work but that another pathway is being employed to make the cancer grow. In our case, Her2 or something else) can occur.
Secondly, there is a fine trial that looked at metastatic women that were ER+ and Her2+. None of the women had been treated yet with anything. Half the women received Arimidex and the other half received Arimidex and Herceptin. The half that got Arimidex and Herceptin didn't have progression for 2 years (versus 9 months with Arimidex only). This convinced me to get my ooph AND helped me convince my onc for 5 extra treatments to keep me on the combo for a full year.
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Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
Last edited by Becky; 07-11-2007 at 04:32 PM..
Reason: Additional Information
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