HER2 Support Group Forums - View Single Post - here we go again: How inexact ER status testing is!!!

TSund · 07-10-2007, 05:02 PM

Lani,

You are about 1000% ahead of me as far as being well read up,

but from what I understand about TOPO is that the latest info about Her2+ and TOPO flies in the face of what was thought previously. When Her2+ and Herceptin enters the equation, all of a sudden the anthrcycline is not necessary in chemo to achieve similar results (i.e the latest stats on TCH - San Antonio). The TOPO positive people do better in general, and that is true in HER2+ whether they do the AC+TH or TCH. I was given this answer when I asked our onc if the fact that Ruth was responding well to the TCH meant that she was TOPO negative as the other onc (not a bc specialist) had given us the hard core insistence that Ruth must have an anthracycline in case she was TOPO positive. I think I read something early on by Dr. Pegram (sp?) that indicates something similar.

07-10-2007, 05:02 PM	#18
TSund Senior Member Join Date: May 2007 Location: DFW area (TX) Posts: 431	changing status of TOPO ll + HER2 Lani, You are about 1000% ahead of me as far as being well read up, but from what I understand about TOPO is that the latest info about Her2+ and TOPO flies in the face of what was thought previously. When Her2+ and Herceptin enters the equation, all of a sudden the anthrcycline is not necessary in chemo to achieve similar results (i.e the latest stats on TCH - San Antonio). The TOPO positive people do better in general, and that is true in HER2+ whether they do the AC+TH or TCH. I was given this answer when I asked our onc if the fact that Ruth was responding well to the TCH meant that she was TOPO negative as the other onc (not a bc specialist) had given us the hard core insistence that Ruth must have an anthracycline in case she was TOPO positive. I think I read something early on by Dr. Pegram (sp?) that indicates something similar.