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chrisy · 06-25-2007, 05:45 PM

Ellen, I think I am on the same trial as you are, Tykerb + Avastin, but at UCSF. I started at the end of April. Glad to hear you are feeling better so quickly!

Harald, I had only mild side effects on this combo, but unlike others who have responded to this thread, I take the Tykerb in the morning and was afraid to change because for me, the degree of diahrrea (I STILL can't spell that word!) seemed to correspond to the amount of time before I ate. So I think that if I took it in the evening I'd be up all night! I, too, take 6 tabs a day on the trial.

I keep forgetting that these agents can cause fatigue - I need to stop beating myself up about being tired and lazy!

And Harald, it's wonderful hearing you refer to your wife as "lovely"! I hope this treatment works well and quickly for her.

Take care
Chris

06-25-2007, 05:45 PM	#7
chrisy Senior Member Join Date: Sep 2005 Location: Central Coast, CA Posts: 3,207	Ellen....and Harald Ellen, I think I am on the same trial as you are, Tykerb + Avastin, but at UCSF. I started at the end of April. Glad to hear you are feeling better so quickly! Harald, I had only mild side effects on this combo, but unlike others who have responded to this thread, I take the Tykerb in the morning and was afraid to change because for me, the degree of diahrrea (I STILL can't spell that word!) seemed to correspond to the amount of time before I ate. So I think that if I took it in the evening I'd be up all night! I, too, take 6 tabs a day on the trial. I keep forgetting that these agents can cause fatigue - I need to stop beating myself up about being tired and lazy! And Harald, it's wonderful hearing you refer to your wife as "lovely"! I hope this treatment works well and quickly for her. Take care Chris __________________ Chris in Scotts Valley June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?" 9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++ 10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response! 04/05 - 4/07 Herception every 3 wks, Continue NED 04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial 06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin 01/08 Progression in liver 02/08 Begin (TDM1) trial 08/08 NED! It's Working! Continue on TDM1 02/09 Continue NED 02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED 12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver 07/11 - 11/11 Herceptin/Xeloda -not working:( 12/11 Begin MM302 Phase I trial - bust:( 03/12 3rd times the charm? AKT trial 5/12 Scan shows reduction! 7/12 More reduction!!!! 8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!) 9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3 11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc 11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go. 2/13 Gemzar/Carbo/Herceptin - no go. 3/13 TACE procedure