View Single Post
Old 06-25-2007, 02:54 PM   #31
fullofbeans
Senior Member
 
Join Date: Jan 2007
Location: UK
Posts: 617
Hi All

Firstly thank you R.B for your post and the extremely interesting paper:
http://content.febsjournal.org/cgi/c...ull/274/6/1393

The comments regarding the fact that oxidative process also exist in tumour cells is disturbing. But as mentioned in the video the mutation in the hypoxic zone are the one to watch for, these are the cells that will eventually become undifferentiated and resistant to any treatment. So the way I see if you can rid of them only it is already progress.

Secondly it will varie from people to people as we all know a drug works on someone and not on someone else who has the same cancer, subtle variation in mutation is the likely explanation.

Anyhow I will print that paper and give it great consideration and you are right there is not enough time to read everything. I need to revise on my biochemistry..

I had prepared an answer about the use of Ketone body by the brain (when fasting) not just glucose but just notice that R.B has been on the case..

In reply to R.B about time frame : 24 hour. Glycogene store (3%) of liver weight are used used within 24hour after which ketogenesis occurs. Protein is not broken down to produce glucose until there are no fat left effectively when you are starving not fasting (using fat reserve). Maintenance of blood glucose is a difficult mechanism which is still poorly understood and I have emailed someone about it as I want to underrstand it more. But in the meantime it is sufficient to know that glucose is no longer used when fasting because hormonal changes depresses insulin production by feedback mecanism (therefore if your cancer cell is sentive to insulin then you are still helping, the way I see it). And providing that you are not exercising above ketogenis level (i.e. do not require glucose) i.e. not running for long ect then glucose is likely to be left untouched. You can walk for many hours and still not require glucose however if you need to exercise because say you are running away from an attack, adrenaline will save the day..but I will stop here basically take home message if you are fasting to cut off glucose availability do not exercise hard since lactic acid can be transformed back into glucose, one would presume to allow us to run away from life threatening situation..god we are so well made!!

Adrianna: Regarding the comment from my surgeon I agree he is an idiot, but perhaps he has spurred on a awareness of my precarious condition and therefore a new fight in me by using every available knowledge I have accumulated..I was starting to be slack with my diet.. when he said that I answered " I hope that I will prove you wrong".

I am sorry to hear that your cancer came back after so long it must have been hard.. big mental hug..
__________________

35 y/o
June 06: BC stage I
Grade 3; ER/PR neg
Her-2+++; lumpectomies

Aug 06: Stage IV
liver mets: 6 tumours
July 06 to Jan 07: 2*FEC+6*Taxotere; 3*TACE; LITT
March 07- Sept 07: Vaccination trial (phase 2, peptide based) at the UW (Seattle).
Herceptin since 2006
NED til Oct 09
Recurrence Oct 2009: to internal mammary gland since October 2009 missed on Oct and March 2010 scan.. palpable nodes in May 2010 when I realised..
Nov 2011:7 mets to lungs progressing fast failed hercp/tykerb/xeloda combo..

superior vena cava blocked: stent but face remains puffy

April 2012: Teresa Trial, randomised to TDM1
Nov 2012 progressing on TDM1
Dec 2012 blockage of my airways by tumours, obliteration of these blocking tumours breathing better but hoping for more- at mo too many tumours to count in the lungs and nodes.

Dec 2012 Starting new trial S-222611 phase 1b dual egfr her2+ inhibitor.



'Under no circumstances should you lose hope..' Dalai Lama
fullofbeans is offline   Reply With Quote