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TSund · 06-24-2007, 01:37 PM

I asked our onc about this very issue on Friday. I asked if the fact that Ruth had responded so well thus far to TCH means that she is TOPO negative as we had been told by the earlier oncologist that we really needed to do AC + TH because it was the "standard of care" and because of the possible TOPO factor. (Ruth has not been tested)

Our new onc said, actually, TOPO positve women in general have a BETTER prognosis than those TOPO negative and this went for either chemo WHEN GIVEN WITH HERCEPTIN. Without the HER2+/Herceptin than the anthracylcines are called for in TOPO 11 positive. I don't know if TOPO positive women had better prognosis pre-Herceptin.

I belive this is also what Pegram has been saying with the latest stats. It would be great to get Slamon's very latest view on this ast his info has really been evolving even in the last few months. I don't believe the article referenced is even quite up to date.

But I am a newbie to this and could have this wrong!

06-24-2007, 01:37 PM	#11
TSund Senior Member Join Date: May 2007 Location: DFW area (TX) Posts: 431	not sure but... I asked our onc about this very issue on Friday. I asked if the fact that Ruth had responded so well thus far to TCH means that she is TOPO negative as we had been told by the earlier oncologist that we really needed to do AC + TH because it was the "standard of care" and because of the possible TOPO factor. (Ruth has not been tested) Our new onc said, actually, TOPO positve women in general have a BETTER prognosis than those TOPO negative and this went for either chemo WHEN GIVEN WITH HERCEPTIN. Without the HER2+/Herceptin than the anthracylcines are called for in TOPO 11 positive. I don't know if TOPO positive women had better prognosis pre-Herceptin. I belive this is also what Pegram has been saying with the latest stats. It would be great to get Slamon's very latest view on this ast his info has really been evolving even in the last few months. I don't believe the article referenced is even quite up to date. But I am a newbie to this and could have this wrong!