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Obviously it depends if it was deleted (only by gene therapy whereby a virus or other vector reinserted the gene), or affected by a "functionally significant"
somatic mutation (see below), or downregulated (see below as well).
If downregulated, either inhibit whatever downregulated it or find something which upregulates (stimulates the production of its gene product)
If mutated, either find a way to silence the mutation or otherwise produce/supply the gene product some other way.
I will be reading the full article in more detail.
These things come stepwise--first you have to discover the culprit gene before you can figure out how to "fix" it or substitute for it.
At least it looks as if they are on the way!!!
By the way, what lethal autoimmune disease is it? I will read about what the mice had and see if it sounds similar.
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