[RobinP]

Amazingly, soy has an antiproliferative effect on hormonal negative breast cancers. This is good news for hormonal negatives. I must warn, though, that hormonal status may change over the course of time. 20% of the hormonal negatives that relapse, convert to hormonal positive.

Other benefits of phyto-estrogens for hormonal negative, her2+s:


Dietary phyto-oestrogens are capable of inhibiting the proliferation epidermal growth factor (EGF),(Her-2). Similar findings were reported in a recent study investigating the chemoprotective effects of the green tea polyphenol epigallocatechin-3 gallate (EGCG). The treatment of Her-2/neu over-expressing mouse mammary cells with 20–80 μg/ml EGCG inhibited proliferation in a dose-dependent manner, correlating with a reduction in Her-2/neu signalling activity [72]. The basal tyrosine phosphorylation of Her-2/neu was decreased by approximately 96% following treatment with 80 μg/ml EGCG. Downstream activities of the signalling proteins phosphoinositide 3-kinase, Akt and nuclear factor-κB were similarly repressed, suggesting a potential clinical application of EGCG in breast cancer therapy.The soy isoflavones have additionally been proposed to regulate the proliferation of breast epithelia via an alternative mechanism involving the modulation of TGF-β synthesis [73].