[Margerie]

The oxygenation discussion- I have been pondering the effects of high altitude and cancer. Haven't found decisive facts, but it is pretty well known that areas of high altitude have lower cancer rates. I know some people move to higher altitudes to help "cure" themselves after a cancer dx. Basically your body pumps up your RBC to compensate for less O2 in the air- would follow the more oxygentation- less cancer theory.

We have a place in the mountains and I can feel the sustained effects for a few days upon my return- my hard hike is easy for a few days, less fatigue during the day, etc.
Wondering if we should move there- LOL my DH would be thrilled!

Also the angiogensis process, immensely complicated. Interestingly enough, as a grad student, studied angiogenic factors' (TIMP specifically) ability to inhibit endothelial call migration. The thinking was we could inhibit new blood vessel formation for tumor growth and shut it down. Now they have found that patients with higher naturally occurring TIMP actually have a worse prognosis. Can't remember the details, but was shocking nonetheless.