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vickie h · 06-07-2007, 05:12 PM

Hi Janet, I did the phase II trial for BIBW for about 10 days, it completely knocked out the skin mets but I was so sick, diarhea, horrible face rash that was painful and just plain awful. They reduced my dose but still too strong, so I took 4 weeks off and have been on Xeloda?Tykerb for about a month and I am doing great. The Tykerb is fantastic and I have no skin mets at all (they came back quickly in that 4 week rest period). I also have hardly any symptoms with the Xeloda (I am taking a reduced dose) or the Tykerb ( I am taking the full 5 tablets). If there is anything I can do to help let me know. Should you experience difficulties with the BIBW, there is also a HKI trial, phse III going on. It is so similat to BIBW and Tykerb, Just minute differences in the formulas, bbut they are all Tyrosine Kinase Inhibitors. Let me know what you decide. Love and Hugs, Vickie

06-07-2007, 05:12 PM	#6
vickie h Senior Member Join Date: Jun 2006 Location: san luis obispo, ca Posts: 1,150	Bibw 2992 Hi Janet, I did the phase II trial for BIBW for about 10 days, it completely knocked out the skin mets but I was so sick, diarhea, horrible face rash that was painful and just plain awful. They reduced my dose but still too strong, so I took 4 weeks off and have been on Xeloda?Tykerb for about a month and I am doing great. The Tykerb is fantastic and I have no skin mets at all (they came back quickly in that 4 week rest period). I also have hardly any symptoms with the Xeloda (I am taking a reduced dose) or the Tykerb ( I am taking the full 5 tablets). If there is anything I can do to help let me know. Should you experience difficulties with the BIBW, there is also a HKI trial, phse III going on. It is so similat to BIBW and Tykerb, Just minute differences in the formulas, bbut they are all Tyrosine Kinase Inhibitors. Let me know what you decide. Love and Hugs, Vickie __________________ Love and Hugs, Vickie Life's not about waiting for the storm to pass, It's about learning to dance in the rain. Feb 04 IBC IIIC/IV er-/pr- her2+++ 3/04 TCH X4 7/ 04 MRM 9/04 Taxol/herceptin wkly 1 yr 33X rads 11/04 skin mets 33x rads,10/05 Avast/Herc. 11 mos. 8/ 06 PET mets lymphs, neck 9/ 06 Navelbine/herceptin 11/ 06 PET NED 2/ 07 skin mets, 4/07 Xeloda, 5/07 add Tykerb 2/ 08 Tykerb failed. Doxil /Herceptin 6 months 8/08 PET skin mets, 8/08 Abraxane/Avastin 11/ 08 PET prog., skin mets 1/09 PET/CT progress, 1/09 Ixempra, 2/09 add Xeloda and low dose Naltrexone 2/09 off Ixempra/Xeloda 3/09 navelbine/herc/cytoxin 4/09 PET shows regress.7/09 start Topotecan. Failed. 8/09 extensive mets rgt brst, back and torso. starting Pazopanib clinical trial.