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I have seen a single case on another board of mets to brain only. So, it is possible I presume. But, I think yes is the generalized answer to your question.
My other mets were minimal: mediastinal node/s with unconfirmed spots on lung and pelvis just prior to brain mets dx. Since one of my first two tumors was 1.5cm, I think it is safe to say that it was present at that very first dx of mets, two months prior to brain MRi.
I've remained NED in body for coming up on five yrs, without any systemic treatment. Altho' I guess you could say that Xeldoa (for latest brain mets) for near two yrs could be a contibuting factor at this point. Just don't know.
Warmly,
pattyz
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