HER2 Support Group Forums - View Single Post - Trastuzumab-MCC-DM1

Barbara H. · 05-18-2007, 01:55 PM

I am stage 4 and progressing with bone mets. Originally diagnosed 1998 with 7 out of 9 lymph nodes. May, 2004: 3cm tumor to left pre-frontal cortex, liver, skin, lung mets, and in the nodes through out. After a few rounds of Herceptin I went into remission until February 06 when I developed bone mets. Navelbine and Zometa was added for bone mets. Dropped Navelbine Dec 06.

Description of trial: A phase 1 open-label, dose-escalation study of the sagety and pharmacokinetics of Trastuzumab-MCC-DM1(PRO132365) administererd intravenously to patients with HWE2-positive metastatic breast cancer who have previously received a Trastuzumab-containing regimen.

I am curious if anyone has heard anything about this trial. I have read a few things about it on the internet.

Thanks,
Barbara H.

05-18-2007, 01:55 PM	#4
Barbara H. Senior Member Join Date: Sep 2005 Location: Newton, MA Posts: 951	Trial I am stage 4 and progressing with bone mets. Originally diagnosed 1998 with 7 out of 9 lymph nodes. May, 2004: 3cm tumor to left pre-frontal cortex, liver, skin, lung mets, and in the nodes through out. After a few rounds of Herceptin I went into remission until February 06 when I developed bone mets. Navelbine and Zometa was added for bone mets. Dropped Navelbine Dec 06. Description of trial: A phase 1 open-label, dose-escalation study of the sagety and pharmacokinetics of Trastuzumab-MCC-DM1(PRO132365) administererd intravenously to patients with HWE2-positive metastatic breast cancer who have previously received a Trastuzumab-containing regimen. I am curious if anyone has heard anything about this trial. I have read a few things about it on the internet. Thanks, Barbara H.