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Thanks Lolly!
Technically, Gemzar and Xeloda have a molecular weight small enough to cross the bbb. And Temodar does as well ofcourse, being developed for primary brain cancers.
Tykerb is not a chemotherapy agent but a targeted therapy like Herceptin.
Some other chemos may cross the bbb through a 'thinning' of the bbb from radiations, other drugs, or the brain mets themselves.
pattyz
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