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Terri,
I am sorry we have to meet you under these circumstances. Your spouse has a wonderful, supportive advocate in you. I wanted to respond to your question about PR+. If you search the Board, you will find links to various articles about ER+/PR- Her2+ bc, which is considered to be "more aggressive" than ER+/PR+ bc. The theory is that the PR pathway is usurped by additional growth factor signaling in PR- Her2+ cases. It is therefore better to be PR+, as it indicates the PR signaling is "intact." I found one study that said that PR+ had stronger prognostic value than Her2+; that PR+ was more significant for disease free and overall survival.
Best of luck to you both,
Hopeful
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