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Becky · 05-08-2007, 06:05 AM

Both are very good regimens. Almost 3 years ago one did not have a choice. The standard of care was AC followed by Taxol (then if Her 2 - with Herceptin added). However, last year's ASCO (june, 2006) showed that TCH was just as good as AC followed by TH in preventing recurrence AND - it had reduced heart toxicity AND reduced the rare side effect occurence of secondary leukemia (most like due to Adriamycin).

So - especially for stage 1, TCH may be the wave of the future because of effectiveness plus it is well documented that a taxane (ie: Taxol, Taxotere, Abraxane) greatly improves lack of recurrence and disease free survival in Her2+ women (regardless of hormone status).

Hope this helps.

05-08-2007, 06:05 AM	#6
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Both are very good regimens. Almost 3 years ago one did not have a choice. The standard of care was AC followed by Taxol (then if Her 2 - with Herceptin added). However, last year's ASCO (june, 2006) showed that TCH was just as good as AC followed by TH in preventing recurrence AND - it had reduced heart toxicity AND reduced the rare side effect occurence of secondary leukemia (most like due to Adriamycin). So - especially for stage 1, TCH may be the wave of the future because of effectiveness plus it is well documented that a taxane (ie: Taxol, Taxotere, Abraxane) greatly improves lack of recurrence and disease free survival in Her2+ women (regardless of hormone status). Hope this helps. __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"