[RobinP]

Pat, I think it is important to remember that everyone has different reactions to meds. Herceptin may be doing this with some kind of delayed kick in side effect response; although, it is probably likely that it would have happened sooner. Also, I would ride this out a bit before you go on a serious witch hunt of reasons why this is happening. It may just blow over soon for you, which i hope it does.

Jean, please don't be so anxious to switch to IV biphosphonates just because they sound more convienent. The IV form has a MUCH greater risk for osteonecrosis of the jaw which is not very treatable, if it does happen. I would never take the IV form unless it was really a severe bone loss situation, as the oral form is a safer alternative.