HER2 Support Group Forums - View Single Post - how alcohol consumption increases risk of bc and growth of breast cancer elucidated

Lani · 04-30-2007, 09:16 PM

Of the several mechanisms they postulate, only one applies to ER+s and most her2+s are associated with increased VEGFR.

I recently cited the only article I have ever found looking at the association of dietary factors and her2+ breast cancer only. Most articles look at environmental or dietary associations either with ALL breast cancers or with ER+ breast cancers or ER- breast cancers.

As her2+ ER- breast cancers make up about 12% of breast cancer and
her2+ER+ breast cancer about 10% of breast cancer, I think you will have to wait a long time before studies looking at the association of alcohol and these subtypes of breast cancer are published.

By the way, all these studies are of limited value as they are retrospective studies (looking back at what people remember or say they remember or did) vs enrolling patients and seeing how the possible risk factor in fact, affected the rate of breast cancer in the group.

Of course, diet is not the ONLY THING different in these groups--they cannot be truly controlled experiments.

04-30-2007, 09:16 PM	#4
Lani Senior Member Join Date: Mar 2006 Posts: 4,783	actually this study only proves it applies to mice! Of the several mechanisms they postulate, only one applies to ER+s and most her2+s are associated with increased VEGFR. I recently cited the only article I have ever found looking at the association of dietary factors and her2+ breast cancer only. Most articles look at environmental or dietary associations either with ALL breast cancers or with ER+ breast cancers or ER- breast cancers. As her2+ ER- breast cancers make up about 12% of breast cancer and her2+ER+ breast cancer about 10% of breast cancer, I think you will have to wait a long time before studies looking at the association of alcohol and these subtypes of breast cancer are published. By the way, all these studies are of limited value as they are retrospective studies (looking back at what people remember or say they remember or did) vs enrolling patients and seeing how the possible risk factor in fact, affected the rate of breast cancer in the group. Of course, diet is not the ONLY THING different in these groups--they cannot be truly controlled experiments.