HER2 Support Group Forums - View Single Post - Exercise and IGF-1 and her2??????

Becky · 04-06-2007, 09:20 PM

If Newsweek stated that IGF-1 causes cancer or Herceptin resistance, they may not have fully understood the concept and miswrote.

SOME cancers, including bc, can have an overexpression of IGFR (R is for receptor like ER for estrogen receptor). We need IGF (just like we need Her2 protein) but with too many receptors, cancer can grow out of control. So, let's say that you are Her2+ and IGFR+. The Herceptin works on the Her2 but nothing is working on the IGFR. If your cancer comes back, you might say that you had Herceptin resistance but in reality, your cancer is just growing via another pathway.

IGF-1 is controlled and normalized by three things - proper low glycemic diet, normal to subnormal weight and most IMPORTANTLY exercise (which normalizes insulin production and use).

So, exercise is very important. So get those walking shoes on!

04-06-2007, 09:20 PM	#6
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	If Newsweek stated that IGF-1 causes cancer or Herceptin resistance, they may not have fully understood the concept and miswrote. SOME cancers, including bc, can have an overexpression of IGFR (R is for receptor like ER for estrogen receptor). We need IGF (just like we need Her2 protein) but with too many receptors, cancer can grow out of control. So, let's say that you are Her2+ and IGFR+. The Herceptin works on the Her2 but nothing is working on the IGFR. If your cancer comes back, you might say that you had Herceptin resistance but in reality, your cancer is just growing via another pathway. IGF-1 is controlled and normalized by three things - proper low glycemic diet, normal to subnormal weight and most IMPORTANTLY exercise (which normalizes insulin production and use). So, exercise is very important. So get those walking shoes on! __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"