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heblaj01 · 03-13-2007, 09:46 PM

Joe/Christine,

Based on the lab study below does GSK believe that adding Tykerb to Herceptin after resistance to Herceptin has set in is likely to be more effective than Tykerb alone in advanced cancer?
Would the answer also apply to early cancer?
Is the Tykerb+Herceptin combo likely to delay resistance in any situation?

http://mct.aacrjournals.org/cgi/con...bstract/6/2/667
Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: effects on insulin-like growth factor I signaling

P.S.
Tykerb is approved but is GSK ready to mass produce the pills or when will it be ready to supply any demand?

03-13-2007, 09:46 PM	#17
heblaj01 Senior Member Join Date: Apr 2006 Posts: 543	Joe/Christine, Based on the lab study below does GSK believe that adding Tykerb to Herceptin after resistance to Herceptin has set in is likely to be more effective than Tykerb alone in advanced cancer? Would the answer also apply to early cancer? Is the Tykerb+Herceptin combo likely to delay resistance in any situation? http://mct.aacrjournals.org/cgi/con...bstract/6/2/667 Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: effects on insulin-like growth factor I signaling P.S. Tykerb is approved but is GSK ready to mass produce the pills or when will it be ready to supply any demand? Last edited by heblaj01; 03-13-2007 at 10:30 PM.. Reason: Added one question