Jean,
Lani is likely to provide a thorough answer to your question when able to respond.
In the meantime here are two bits of info from previous posts:
http://www.sciencedaily.com/releases...0111121906.htm
Novel Regulation Of The Common Tumor Suppressor PTEN
http://www.her2support.org/vbulletin...ad.php?t=24955
I3C upregulates PTEN--could broccoli make herceptin work better?
Also posts #11 & 12 in this thread:
http://www.her2support.org/vbulletin...ad.php?p=77534