[Joy]

I have also been on this combination. I started end of August 2006. So I have been on a weekly schedule for 6 months. Occasionallly the lower dose is necessary, but I have always been able to receive it. The only pre-med I get is Kytril. It has been my favorite chemo of all that I have been on (A/C-ick, ick, ugh-Taxotere/Xeloda - felt a little beat up-Taxol/Carbo-insidious low grade depression and fatigue).

I'm actually praying that I stay on it. I had good response after 6 weeks and now we are waiting to see what's the what. I'll know this week.

Anyway, I have horrible fingernails (Herceptin, I'm sure). And some cumulative fatigue (actually happy to hear others have had this as I've been feeling like a slacker again). Sometimes I get a yucky taste in my mouth a couple days after, but food largely tastes the same. Constipation has been a problems, but treatable. And the water advice is right on. I'm a good water drinker, but I need a lot more than usual on this combination (especially in Colorado). I also have the nose crusties from herceptin and weird cramps now and again.

But, I have happy new hair that needs to be cut and I feel quite good and can take care of my kids and everybody else's and go out with friends and ignore housework like usual.

Good luck and keep us posted.