[CPA]

If her periods had stopped prior to chemo, I would guess that there is a good chance that she is really in menopause. If they stopped during chemo, then there is a chance that she could re-start her period. We were told that in addition to checking labs, our onc wanted to wait 2 years after Jill's last period before switching to an AI.

At 46, your wife is nearing natural menopause, so ovarian suppression or removal might not be a bad option. It sounds like many docs don't like to stop ovarian function in younger women, especially if there are no mets because of the other protective qualities of the hormones (bones, heart, etc.). Our oncologist seemed to think it was a no-brainer for Jill to go on Tamoxifen, but she is node negative and younger.

In a situation like this you might not find the right answer, rather several good answers with differing risks and benefits.