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Rinaina,
I am not sure anyone knows for certain. I have a file at my office with a few articles I printed out that had some theories on it. I will try and find the links to those articles and post them for you if I do. From memory (which is not the best, these days!) one of them talked about whether the Her2+ receptor was on the cell surface or not (apparently there is some Her2+ with truncated forms) and that since the Herceptin binds to the outside of the cell, if there is nothing on the outside of the cell for it to bind to, it is not effective. Another article said that bc patients with cmyc expression have a very high response rate; another discussed if the tumor has not lost PTEN expression, the PTEN somehow gets the Herceptin into the center of the cell and causes it to die. With any luck, I'll get some of these links so you can read the reasearch.
Hopeful
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