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MGordon · 01-17-2007, 02:16 PM

Lisa was treated with Navelbine but did not tolerate it well. If there was a "possible" side effect listed - she had it. Including hair Loss (supossedly somewhat rare with Navelbine and her third total hair loss). I think she hated the neuropathy the most (numb and tinlgy hands and feet - difficulty with any hand dexterity like buttons and zippers).

My memory is anything but spotless - but I do not believe that Navelbine penetrates an intact blood/brain barrier yet - but I think they are working on platinum-based antieoplastics injected into the central nervous system to reach the brain - Navelbine is alkaloid-based. Has she had WBR? I think they would need to use it in conjunction with a platinum-based compound in any event.

It is used primarily for B/C and Lung cancer, but can be used for Cervical and Ovarian cancer as well. Your onc will want to watch the billirubin levels VERY carefully. I also seem to remember that the University of Florida was studying combining Navelbine with Gemzar and a platinum compound for b/c brain mets.

Sorry but my info is probably dated since Lisa was off of Navelbine over 18 months ago.

Hope SOMETHING in here helps.

Love and Light
Mel

01-17-2007, 02:16 PM	#2
MGordon Senior Member Join Date: Nov 2004 Location: Colorado Posts: 131	Vinorelbine aka Navelbine Lisa was treated with Navelbine but did not tolerate it well. If there was a "possible" side effect listed - she had it. Including hair Loss (supossedly somewhat rare with Navelbine and her third total hair loss). I think she hated the neuropathy the most (numb and tinlgy hands and feet - difficulty with any hand dexterity like buttons and zippers). My memory is anything but spotless - but I do not believe that Navelbine penetrates an intact blood/brain barrier yet - but I think they are working on platinum-based antieoplastics injected into the central nervous system to reach the brain - Navelbine is alkaloid-based. Has she had WBR? I think they would need to use it in conjunction with a platinum-based compound in any event. It is used primarily for B/C and Lung cancer, but can be used for Cervical and Ovarian cancer as well. Your onc will want to watch the billirubin levels VERY carefully. I also seem to remember that the University of Florida was studying combining Navelbine with Gemzar and a platinum compound for b/c brain mets. Sorry but my info is probably dated since Lisa was off of Navelbine over 18 months ago. Hope SOMETHING in here helps. Love and Light Mel __________________ Mel Gordon, Husband of Lisa Lowe - Queen of Love and Light and the bravest person I know!