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Becky · 01-06-2007, 02:58 PM

Dear Hopeful

You are right about the trial. In an evening session at SABCS, Dr Chang and Dr Winer discussed the following trial (of which they still need to submit to the FDA). It is for newly diagnosed early stage (node positive) Her2 bc.

It will run as follows:

4 DD AC followed by 12 Taxol H with 40 weekly Herceptin alone
4 DD AC followed by 12 Taxol with Tykerb with another 40 weeks of Tykerb
4 DD AC followed by 12 Taxol w/ Herceptin AND tykerb followed by 40 weeks of Herceptin and Tykerb.

I am pretty sure that I did not misunderstand that this trial would be 6 armed (concurrent and sequential) and that it would only be concurrent. Sheila, Michelle U, Chrisy, Sandy H, Joe and Christine were at this too (last night of the symposium, Sat. Dec 16). I will look through my books as a brochure of most of the slides were given to each participate. Maybe one of the others can remember it from the top of their head but I am very certain this trial will go this way.

01-06-2007, 02:58 PM	#5
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Dear Hopeful You are right about the trial. In an evening session at SABCS, Dr Chang and Dr Winer discussed the following trial (of which they still need to submit to the FDA). It is for newly diagnosed early stage (node positive) Her2 bc. It will run as follows: 4 DD AC followed by 12 Taxol H with 40 weekly Herceptin alone 4 DD AC followed by 12 Taxol with Tykerb with another 40 weeks of Tykerb 4 DD AC followed by 12 Taxol w/ Herceptin AND tykerb followed by 40 weeks of Herceptin and Tykerb. I am pretty sure that I did not misunderstand that this trial would be 6 armed (concurrent and sequential) and that it would only be concurrent. Sheila, Michelle U, Chrisy, Sandy H, Joe and Christine were at this too (last night of the symposium, Sat. Dec 16). I will look through my books as a brochure of most of the slides were given to each participate. Maybe one of the others can remember it from the top of their head but I am very certain this trial will go this way. __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"