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That was sort of what I was wondering about, if I take Tykerb while I am in remission, would I develope a resistance to it, if I may ever need it later. But then again, I am hoping to stay in remission and not need it later..and I figure the Tykerb would help there. I was on Taxotere, Xeloda and Herceptin for 4 months and after about 6 weeks on those drugs my lung mets were gone, so I know we could always go back to that. Then again, I am so worried about brain mets and if Tykerb helps protect against that, then I can't see not taking advantage of that. I figure the way things are going, they are sure to develop new drugs in the near future that might even be better. I just remember reading that article in "Cure" that I spoke of and it saying how they think Tykerb with Herceptin would be the one/two knockout that may be needed for HER2+. Since one attacks the outside of the cell and the other attacks the inside. I think I am going to get on it as soon as it's available and stay on the Herceptin also. My Oncologist will do whatever I want. I read someone saying they were going to get on Tykerb "off label". What exactly does that mean? If it is approved by February would you still need to get it off label? My Oncologist told me that he has several women who are on Tykerb right now and all of them have been responding to it, he said it was amazing what he has seen. He said the only side effect that he has seen so far is that it makes the biliruben (sp?) in the blood go higher, but the patients haven't noticed anything. ..sherryg683
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