HER2 Support Group Forums - View Single Post - Becky: any further comment on Tykerb compared to Herceptin for response rate.

heblaj01 · 12-21-2006, 05:34 PM

Becky,
you mentioned that at the SABCS you were let to understand by an expert that the anticancer activity of Tykerb was almost entirely with respect to activity against HER-2 not HER-1.
If this is so, for women who are assumed(for the purpose of this hipothetical question) to be HER-2 positive & are neither resistant to Herceptin nor to Tykerb which of the two drugs would be effective in the highest percentage of patients?
I suppose there is no scientific answer to the question but you may have heard some comments providing a few clues or can some tentative conclusions be drawn from the comparison of published clinical trials?

12-21-2006, 05:34 PM	#1
heblaj01 Senior Member Join Date: Apr 2006 Posts: 543	Becky: any further comment on Tykerb compared to Herceptin for response rate. Becky, you mentioned that at the SABCS you were let to understand by an expert that the anticancer activity of Tykerb was almost entirely with respect to activity against HER-2 not HER-1. If this is so, for women who are assumed(for the purpose of this hipothetical question) to be HER-2 positive & are neither resistant to Herceptin nor to Tykerb which of the two drugs would be effective in the highest percentage of patients? I suppose there is no scientific answer to the question but you may have heard some comments providing a few clues or can some tentative conclusions be drawn from the comparison of published clinical trials? Last edited by heblaj01; 12-21-2006 at 05:36 PM.. Reason: missing one word