Emmay,
For possible future use get a look at Panzem article at
http://www.entremed.com/download/pre...b_FINALOUT.pdf
While the article is on gliomas, not brain mets from breast, the fact that Panzen (not yet approved) has antiangiogenesis properties & several other modes of action & is usable alone or in combination with Temodar makes it a drug with potential wide applications.
Clinical trials are mentioned (current & in 2007)