HER2 Support Group Forums - View Single Post - JOE at SABCS: question regarding HER2 vaccine

heblaj01 · 12-16-2006, 12:22 PM

Thanks Becky for your comment. Then I will fire an other question regarding an other presentation at SABCS:

Presentation title: Lapatinib Plus Capecitabine Shows Superior Efficacy Compared to Capecitabine Alone in Patients With Erbb2 Positive Advanced or Metastatic Breast Cancer Initial Biomarker Data. Abstract 2

In a brief summary of the priesentation it is stated that Lapatinib when added to Xeloda is effective in improving progression free survival regardless of the extracellular domain levels which I assume means independant of serum levels of HER-2 protein shed by cancer cells.
Does this mean that the Bayer serum test for HER-2 is not meaningfull for selecting Lapatinib treatment? How about Herceptin?
By the way, the summary states that only 60% of HER-2 cancers cause measurable levels of serum HER-2 a fact I did not know. Is this a recent finding?

12-16-2006, 12:22 PM	#3
heblaj01 Senior Member Join Date: Apr 2006 Posts: 543	Thanks Becky for your comment. Then I will fire an other question regarding an other presentation at SABCS: Presentation title: Lapatinib Plus Capecitabine Shows Superior Efficacy Compared to Capecitabine Alone in Patients With Erbb2 Positive Advanced or Metastatic Breast Cancer Initial Biomarker Data. Abstract 2 In a brief summary of the priesentation it is stated that Lapatinib when added to Xeloda is effective in improving progression free survival regardless of the extracellular domain levels which I assume means independant of serum levels of HER-2 protein shed by cancer cells. Does this mean that the Bayer serum test for HER-2 is not meaningfull for selecting Lapatinib treatment? How about Herceptin? By the way, the summary states that only 60% of HER-2 cancers cause measurable levels of serum HER-2 a fact I did not know. Is this a recent finding?